Hormonal regulation of ovarian and testicular function

The research of Professor Huhtaniemi’s group attempts to unravel hormonal regulation when the ovaries and testes are healthy or disturbed. We study the key genes involved in reproductive hormone production and action, and address the consequences of the alterations in their function on sexual development and fertility.
Our special interest is to understand the function of the two gonadotrophic hormones secreted by the anterior pituitary gland, luteinising hormone (LH) and follicle-stimulating hormone I(FSH), known to be of crucial importance at all stages of reproduction. The novel information obtained will help us to understand normal and disturbed gonadal function at molecular level, which can be used to develop better diagnosis and treatments for reproductive failure.
More specifically, our research has the following translational goals:
1. To understand how the onset of puberty is timed
2. To unravel the molecular mechanisms of function of the pituitary hormones which influence the ovary and testis
3. To understand how hormone-dependent cancers may be induced, and to improve their treatment
4. To develop new methods of male contraception
5. To understand how ageing affects hormone regulation.

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