David MacIntyre

 

Dr David MacIntyre is a Senior Lecturer in Reproductive Systems Medicine. Broadly, his research is focused on understanding the role of inflammation and infection of the reproductive tract during pregnancy. He is particularly interested in understanding how vaginal microbiota and their interactions with the maternal host can influence poor pregnancy outcomes such as miscarriage, preterm premature rupture of membranes (PPROM) and preterm birth. This is achieved through a combination of classical biochemistry methods as well as “systems” modelling approaches that involve integration and analysis of genomic, transcriptomic, microbiomic and metabolic profiling data. It is hoped that will lead to improved diagnostic and predictive tools that will assist in patient stratification and ultimately, improved pregnancy outcomes.

Dr David MacIntyre’s research is focused on understanding the role of inflammation in the onset of term and preterm human labour. He is particularly interested in understanding the implications of the vaginal microbiome in poor pregnancy outcomes such as preterm birth and preterm premature rupture of membranes (PPROM), which is also known as when a woman’s waters break early during her pregnancy. His research team approaches this using both classical biochemistry methods as well as a “systems” approach where data acquired from genomic, transcriptomic and metabolic profiling platforms are integrated and modelled to investigate the interaction between vaginal microbiota and the maternal host. It is hoped that will lead to improved diagnostic and predictive tools that will assist in patient stratification and ultimately, improved pregnancy outcomes.

Kindinger LM, MacIntyre DA, Lee YS, et al., 2016, Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage., Sci Transl Med, Vol:8